| Date | Requester | Request | Endorsement | Comments |
|---|---|---|---|---|
| December 4, 2007 | Proctor and Gamble |
Topical application of Olay Regenerist containing pal-KTTKS amino peptide improves the appearance of ageing skin by reducing fine lines and wrinkles. |  |
Adequately powered randomized placebo-controlled clinical studies were conducted using reliable clinical end-points. The studies design, methodology, results and statistical analysis were reviewed and considered valid. |
| November 5, 2007 | Proctor and Gamble | Topical application of Olay Regenerist containing pal-KTTKS amino peptide doe not adversely affect skin barrier. | |
Skin barrier function was measured using transepidermal water loss meters. This assessment tool has been validated in numerous clinical studies and is considered the industry gold standard. |
| October 26, 2007 | Proctor and Gamble | Olay Total Effects achieved results equivalent to or better than those achieved with Professional Spa Treatments. | |
Two age matched groups of 100 Thai women were randomized to receive a standard professional Spa treatment or to use Olay Total Effects twice daily for 3 weeks. Women completed a comprehensive questionnaire on completion of the study assessing perceived anti-ageing benefits. The results demonstrated that with respect to the questionnaire there was no statistically significant difference between the 2 groups. While this study is unblinded, self-reported assessment of effectiveness is an important measure of outcome. That participants in both arms of the trial scored similar degrees of satisfaction indicates that with respect to the potential anti-ageing benefits measured by the questionnaire twice daily application of Olay Total Effects is equivalent to a Professional Spa treatment. |
| November 20, 2007 | Proctor and Gamble | Topical application of Niacinamide improves the appearance of fine lines and wrinkles, hyperpigmentation, red blotching and skin tone | |
The presence of fine lines and wrinkles, hyperpigmentation and red blotching all contribute to the perception of skin ageing. Each of these parameters is amenable to quantification using a variety of photographic imaging techniques. Measurement of these parameters before and after topical application of Niacinamide was able to identify a numerical improvement the score of each of these parameters that achieved statistical significance. The study was adequately powered, and well conducted. |
| November 20, 2007 | Proctor and Gamble | Topical application of Niacinamide can inhibit the formation of lipid peroxide species. | |
Lipid peroxide species are potentially damaging skin oxidants that could accelerate to the skin ageing process. Application of Niacinamide cream reduces formation of lipid peroxide species. |